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The GSSG/GSH redox couple interacts with other antioxidant enzymes to maintain mitochondrial function and cellular redox homeostasis 584
In addition, individual genetic makeup, responsible for variable metabolic pathways and related drug sensitivity, can also influence the vulnerability of kidneys to nephrotoxicants
Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells
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